Competitive repopulation. A cohort of mice were radio-ablated and transplanted with a 1:1 mixture of FACKO and wild-type bone marrow for a total of 1 × 10⁶ cells. The lines connecting data points indicate the trend of change. (A) Cohort of mice treated with MMC 1 month posttransplantation and observed to 3 months posttransplantation. (B) Control mice as in (A), except with no MMC treatment. (C) Cohort of mice serially transplanted from an MMC-treated mouse and nontreated control in (B). A through E and F through J represent transplant recipients from separate donors. (D) Phosphoimager quantitative data corresponding to the datapoints after serial transplantation in (C). The high contribution of wild-type DNA is readily discernible.