Survival based on V gene mutation status and CD38 expression. (A) Kaplan-Meier plot comparing survival based on the absence (“unmutated”: ^{. . . . . .} ) or presence (“mutated”: ^____) of significant numbers (≥2%) of V gene mutations in 47 B-CLL cases (unmutated: 24 cases; mutated: 23). Median survival of unmutated group: 9 years; median survival of mutated group not reached; P = .0001; log-rank test). (B) Kaplan-Meier plot comparing survival based on the detection of ≥30% (^{. . . . . .} ) or <30% CD38⁺ B-CLL cells ( ≥30%: 17 cases; <30%: 19). Median survival of the ≥30% CD38⁺ group: 10 years; median survival of the <30% CD38⁺ group: not reached (P = .0001; log-rank test).