Internalization of c-Kit is impaired in Lyn-deficient cells. The DT40-c-Kit and the Lyn-deficient D33-3-c-Kit cells were incubated in SCF (200 ng/mL) for 1 hour at 37°C, and analyzed for c-Kit internalization by flow cytometry as described in Fig 4. The results of one of six similar experiments is shown.