Effect of IFN- treatment on the levels of hybrid BCR/ABL mRNA in bone marrow mononuclear cells from CML patients with complete or poor hematologic responses to therapy. For each patient, values have been adjusted for the percentage of Ph⁺ cells. At diagnosis, the amount of transcript was similar in the 2 groups of patients; there was a significant difference (P < .01, paired t-test) between the values at diagnosis and those at the end of the study in the group of responder patients, whereas in patients resistant to IFN-, there was a trend toward higher values at the end of the study.