Fig. 7.
A comparison of the biological activity of wt-SCF248 and wt-SCF220 withSl17H-SCF248 andSl17H-SCF220 isoforms of SCF. G1E-ER2 cells were cocultured for 24 to 48 hours with parentalSl/Sl4 stromal cells or (A) stable stromal cell transfectants expressing wt-SCF248 orSl17H-SCF248 SCF or (B) stable stromal cell transfectants expressing wt-SCF220 orSl17H-SCF220 SCF. Proliferation was measured by thymidine incorporation assay. Results show the mean ± SEM of a representative experiment performed at least twice with more than 1 clone in replicates of 6. *P < .05Sl/Sl4 v wt (SCF248 and SCF220); **P < .05 Sl/Sl4 v Sl17H (SCF248 and SCF220); and P < .05 wt (SCF248 and SCF220) v Sl17H(SCF248 and SCF220). Note difference in scale between (A) and (B).