Fig. 6.
Fig. 6. As2O3 treatment induces caspase-3 activation but not Bcl-2 degradation. (A) Activation of CPP32 and lack of Bcl-2 modulation after 3 days of treatment with the indicated doses of As2O3. (B) Effect of the same As2O3 treatment on DNA fragmentation. (C) Caspase inhibitor Z-VAD-FMK blocked As2O3-induced apoptosis. NB4 cells were treated for 3 days with 1 μmol/L As2O3 or 200 μmol/L Z-VAD-FMK alone or in combination; Z-VAD-FMK was added 4 hours before the addition of As2O3.

As2O3 treatment induces caspase-3 activation but not Bcl-2 degradation. (A) Activation of CPP32 and lack of Bcl-2 modulation after 3 days of treatment with the indicated doses of As2O3. (B) Effect of the same As2O3 treatment on DNA fragmentation. (C) Caspase inhibitor Z-VAD-FMK blocked As2O3-induced apoptosis. NB4 cells were treated for 3 days with 1 μmol/L As2O3 or 200 μmol/L Z-VAD-FMK alone or in combination; Z-VAD-FMK was added 4 hours before the addition of As2O3.

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