Fig. 5.
Fig. 5. Effects of IL-3 treatment on lymphocyte function. CD8-mediated cytolytic activity of IL-3–treated Jak3−/− splenocytes after challenge with allogeneic P815 tumor cells. P815 cells were injected into wild-type (+/+) mice, Jak3-deficient (−/−) mice, or Jak3−/− mice receiving IL-3 (IL-3) in the presence or absence (CD8−) of CD8+ T cells. The CTL response from pooled splenocytes was measured 14 days after the administration of P815 cells (n = 2 in each group). Triplicate wells for each sample were analyzed and the mean value is shown. The effector to target ratios of 30:1 (▪) are presented using either (A) allogeneic P815 or (B) syngeneic SVB6KHA target cells. This experiment is representative of 3 independent experiments. (C) Survival of mice after influenza A HKx31 virus infection (n = 7 in each group). Control-treated Jak3−/− mice (−/−; •), IL-3–treated Jak3−/− littermates (−/− IL-3; ○), and Jak3+/+ mice (+/+; □).

Effects of IL-3 treatment on lymphocyte function. CD8-mediated cytolytic activity of IL-3–treated Jak3−/− splenocytes after challenge with allogeneic P815 tumor cells. P815 cells were injected into wild-type (+/+) mice, Jak3-deficient (−/−) mice, or Jak3−/− mice receiving IL-3 (IL-3) in the presence or absence (CD8−) of CD8+ T cells. The CTL response from pooled splenocytes was measured 14 days after the administration of P815 cells (n = 2 in each group). Triplicate wells for each sample were analyzed and the mean value is shown. The effector to target ratios of 30:1 (▪) are presented using either (A) allogeneic P815 or (B) syngeneic SVB6KHA target cells. This experiment is representative of 3 independent experiments. (C) Survival of mice after influenza A HKx31 virus infection (n = 7 in each group). Control-treated Jak3−/− mice (−/−; •), IL-3–treated Jak3−/− littermates (−/− IL-3; ○), and Jak3+/+ mice (+/+; □).

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