Expression profile of hCD4 in hematopoietic tissues of HS21/45 vav-hCD4 progeny mice. Nucleated bone marrow (A) B220⁺, (B) IgM⁺, and (C) IgD⁺B-lymphoid cells; (D) Mac1⁺ myeloid cells; (E) Ter119⁺ erythroid cells; and splenic (F) Thy1⁺ T cells. Quadrants were set so that the marker⁺ hCD4⁺ cells in a nontransgenic control sample, run in parallel, did not exceed 5% of total marker⁺ cells analyzed. As would be expected, essentially all cells from the nontransgenic controls then fell in the left quadrants, and the percentage of cells bearing each lineage-specific marker (eg, B220) was similar to that of the corresponding transgenic population.