Thrombin generatin on 200 μmol/L PCPS at varying procoagulant and anticoagulant concentrations in the absence of protein C pathway. Thrombin generation was initiated by 5 pmol/L factor VIIa-TF in the presence of all proteins at mean plasma concentrations (▪), in the presence of procoagulants (prothrombin, factors V, VIII, IX, and X) at 150% and anticoagulants (AT-III and TFPI) at 50% of their mean plasma concentrations (•), and in the presence of procoagulants at 50% and anticoagulants at 150% of their mean plasma concentrations (▴).