Thrombin generation on 200 μmol/L PCPS at varying prothrombin (A) or AT-III (B) concentrations in the presence of protein C pathway. Thrombin generation was initiated by 5 pmol/L factor VIIa-TF in the presence of prothrombin or AT-III at 100% (▪), 150% (•), and 50% (▴) of their mean plasma concentration. All other proteins were present at mean plasma concentrations.