Fig. 2.
Addition of 3:1 platelets to the THP-1 suspension causes a left shift in the shear response. THP-1 cell rolling and adhesion to PMA-activated HUVEC (▴) was only detectable at shear rates less than 400 s−1. The addition of 3 TRAP-activated platelets per THP-1 cell (•) supported dynamic and firm interactions up to 600 s−1. Rolling (A) and adhesion (B) of THP-1 cells similarly increased with the addition of activated platelets to the suspension (n = 6, for each condition, *P < .01v PMA-activated HUVEC in the absence of platelets).
