Effect of genistein on CD43-induced chemokine production and NK cell cytotoxicity. (A and B) IL-2–activated NK cells were incubated for 1 hour in (▪) complete medium or complete medium in the presence of (□) 30 μmol/L genistein or an equivalent amount of (▩) disolvent dimethyl sulfoxide (DMSO). Anti-CD43 TP1/36 or anti-CD44 HP2/9 MoAbs were then added and cells were incubated for additional 4 hours. Chemokines present in cell supernatants were measured as described above. The arithmetic mean ± SE of 3 experiments performed with cells from different donors is shown.