American Society of Hematology

Fig. 3.

$Fig. 3. Representative dot plots comparing CD45RA and CD45R0 expression by normal (CD48+) and PNH (CD48−) lymphocytes for CD4+ (T-helper) and CD8+ (T-cytotoxic) populations. Plots A and B show that the proportion of CD45RA+ cells is significantly higher (75% and 94%, respectively) for PNH components of the CD4+ and CD8+ subpopulations when compared with the residual normal components (28% and 57%, respectively), which are predominantly CD45RA−. Plots C and D are representative examples comparing CD45R0 expression by normal (CD59+) and PNH (CD59−) lymphocytes for CD4+ (T-helper) and CD8+ (T-cytotoxic) populations. As expected, the proportion of CD45R0+ cells is significantly lower (16% and 2%, respectively) for PNH components of the CD4+ and CD8+ subpopulations when compared with the normal components (44% and 57%, respectively). Plots E and F show the proportions of CD45RA+ components within the normal and PNH fractions of the CD4+ and CD8+ lymphocyte subsets of patient PNH030, who had a spontaneous remission of PNH 20 years ago. The plots show normal distributions of naive (CD45RA+) and memory cells (CD45RA−) for all populations.$

Representative dot plots comparing CD45RA and CD45R0 expression by normal (CD48⁺) and PNH (CD48⁻) lymphocytes for CD4⁺ (T-helper) and CD8⁺ (T-cytotoxic) populations. Plots A and B show that the proportion of CD45RA⁺ cells is significantly higher (75% and 94%, respectively) for PNH components of the CD4⁺ and CD8⁺ subpopulations when compared with the residual normal components (28% and 57%, respectively), which are predominantly CD45RA⁻. Plots C and D are representative examples comparing CD45R0 expression by normal (CD59⁺) and PNH (CD59⁻) lymphocytes for CD4⁺ (T-helper) and CD8⁺ (T-cytotoxic) populations. As expected, the proportion of CD45R0⁺ cells is significantly lower (16% and 2%, respectively) for PNH components of the CD4⁺ and CD8⁺ subpopulations when compared with the normal components (44% and 57%, respectively). Plots E and F show the proportions of CD45RA⁺ components within the normal and PNH fractions of the CD4⁺ and CD8⁺ lymphocyte subsets of patient PNH030, who had a spontaneous remission of PNH 20 years ago. The plots show normal distributions of naive (CD45RA⁺) and memory cells (CD45RA⁻) for all populations.

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