(A) Histology of SJL/J spinal cords from mice infected with TMEV. Section of spinal cord of an SJL/J mouse, 130 days after infection with TMEV. The right anterior column is completely demyelinated and numerous large lipid-laden macrophages are present close to the central sulcus. The gray uniform background reflects conspicuous gliosis in the demyelinated area (1-μm–thick, Epon-embedded section, stained with toluidine blue; original magnification × 220). (B) Section from spinal cord of an SJL/J mouse 130 days after infection with TMEV and after treatment with radiation and BMT. Inflammatory cells are still around the large venule in the parenchyma of the left anterior column, indicating active disease, but many axons are still surrounded by myelin sheaths and gliosis is less prominent (1-μm–thick, Epon-embedded section, stained with toluidine blue; original magnification × 220).