Fig. 4.
Specificity of CD137-induced monocyte proliferation. 105 peripheral monocytes were cultured on plates coated with 1 μg/mL of Fc, CD137-Fc protein, anti–HLA-DR antibody, or a fusion protein consisting of the extracellular domain of the type 2 TNF receptor and the constant domain of immunoglobulin G1 (TNFRII-Fc). Proliferation was determined at day 8 by 3H-thymidine incorporation and comparable results were obtained in 2 independent experiments.
