Inhibition of IL-8–induced changes in L-selectin and CD18 expression on human PMNL. Whole blood was preincubated with LXA₄ analogs for 30 minutes and then challenged with 10 nmol/L IL-8 for 30 minutes at 37°C. Adhesion molecule expression is presented as the percentage of control (unchallenged cells). Mean fluorescence intensity for L-selectin: control, 115 ± 8; IL-8, 61 ± 5; CD18: control, 45 ± 4; IL-8, 59 ± 9; n = 3; bothP < .05. Values are the means ± SEM of 3 experiments with different donor cell preparations. *P < .05 vIL-8–stimulated cells.