Fig. 7.
LXA4 analogs prevent cell activation-independent downregulation of L-selectin expression on human PMNL, monocytes, and lymphocytes. Whole blood aliquots were incubated with LXA4 analogs for 30 minutes at 37°C and then challenged with 100 μg/mL CRP peptide 201-206. Results are presented as the percentage of control (unchallenged cells). Mean fluorescence intensity for L-selectin: PMNL, control, 97 ± 6; peptide 201-206, 50 ± 14; monocytes, control, 35 ± 4; peptide 201-206, 22 ± 7; lymphocytes, control, 61 ± 4; peptide 201-206, 51 ± 4; n = 3; allP < .05. Values represent the mean ± SEM of 3 independent experiments. *P < .05 v peptide 201-206–stimulated cells.
