Effects of MAPK kinase (MEK) and tyrosine kinase inhibitors on neutrophil adhesion molecules. Isolated neutrophils (10⁷ cells/mL) were preincubated with PD98059, wortmannin, or genistein for 30 minutes at 37°C and then challenged with 5 μmol/L 15-R/S-methyl-LXA₄ for 30 minutes. Adhesion molecule expression is presented as the percentage of control. Mean fluorescence intensity for control samples, L-selectin: 35 ± 1; CD18: 82 ± 14; n = 4. Values are the mean ± SEM of 4 independent experiments.