Doxycycline-induced expression of BCR/ABL in TonB210.1 cells impairs chemotaxis to SDF-1. The Ba/F3 cell line, TonB210.1, which expresses BCR/ABL in the presence of doxycycline, was tested (n = 4) for a chemotactic response to medium alone (Neg Ctrl), MS-5 supernatant, and SDF-1 (100 ng/mL) using a transwell assay system. The open bars represent control cells (minus doxycycline) and solid bars represent doxycycline-treated cells. Panel A shows the percentage of migrating cells and panel B shows the chemotactic index.