Fig. 5.
Determination of the restriction element of T-cell clones upon inhibition of TT-specific proliferation with specific MoAbs. Percentage blocking of TT-specific proliferation was determined using anti-CD4 (RIV6), anti-MHC class I (W6/32), anti-MHC class II (PdV5.2), and anti-HLA DR (B8.11.2) MoAbs. In each experiment, autologous B-cell lines were used as APC. Percentage inhibition was calculated as follows:100 − (SI TT+MoAb/SI TT alone × 100%). Shown are the results of 2 representative T-cell clones ([▪] UPN275 cl 40 and [▩] UPN 285 cl 2).