Segregation of the mutations analyzed in families PS 23, PS 2, PS 214, APCS 13, PS 225, PS 5, and PS 17.

Filled and half filled symbols, type I and type III protein S deficiency, respectively; dotted symbols, individuals not tested; arrow, propositus; T, thrombotic disease. The genotypes for the G441C, Y444C, R520G, P626L, I518 mol/L, and T57S mutations are indicated below each symbol. The pedigrees of families PS 214 and PS 225 are taken from Figures 1 and 3 of reference 43.