Comparison of eosinophil peritoneal recruitment in IL-1 R type 1 deficient and wild-type mice.

Ragweed-sensitized mice (IL-1 R type 1-deficient or control wild-type mice) (n = 3 experiments) were challenged with an intraperitoneal injection of ragweed allergen. Forty-eight hours later the percentage of transmigrated peritoneal eosinophils was assessed by light microscopy. IL-1 R type 1-deficient mice developed significantly less peritoneal eosinophilia than control wild-type mice after allergen challenge (P = .02).