Fig. 4.
![Fig. 4. Defective APC function in anti-CD3ɛ–treated mice. Spleen cells from control antibody-treated or anti-CD3ɛ–treated BALB/c mice (50 μg IV) were irradiated and used as accessory cells to stimulate (A and B) G10-nonadherent responding cells from CBA mice (3 × 105/well) or (C) ovalbumin-specific T-cell hybridoma mice (3 × 105/well) in the presence of 1 μg/mL of ovalbumin peptide. Proliferation (A) and IL-2 production (B and C) were assayed as described in Materials and Methods. Results are expressed as counts per minute (cpm) of [3H] TdR incorporation by responder cells (A) or IL-2–dependent cell line CTL.L (B and C). These results are representative of 3 independent experiments.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/94/12/10.1182_blood.v94.12.4347/5/blod42431004x.jpeg?Expires=1735839873&Signature=a4PBEkEtiUm2L65FU8iFxhdMLgVdXJX5M-DBf-6-Rlaihh05DqjBw~WAFR5AAxIPUOo6vVgkh2gQ94jlkoXB2-ZEf1sbo1OOt7pJ0lotOMo0PuvJ2D90f~xVugEy0MfobUMrxmaN-8SNaeIvQdOSvjVDCJh4L1tYRQlPnBLRAXMq-8j8IT4JiB0azqD-M2nWUxWjVRr3BcODJbP4htfy9Yx0oKhaxxZD~aBvtV8Q9jLLq5lOg1WXrTLJyHPUat6NAoqHDrl3xUgP3ZzqQ0nzwmuxWRxG55f1zxq9Q-yeSlj~xLr0PXEeZsKkdHOzqluS7FjBBgS4VYM~qF6gk6kLJw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Defective APC function in anti-CD3ɛ–treated mice. Spleen cells from control antibody-treated or anti-CD3ɛ–treated BALB/c mice (50 μg IV) were irradiated and used as accessory cells to stimulate (A and B) G10-nonadherent responding cells from CBA mice (3 × 105/well) or (C) ovalbumin-specific T-cell hybridoma mice (3 × 105/well) in the presence of 1 μg/mL of ovalbumin peptide. Proliferation (A) and IL-2 production (B and C) were assayed as described in Materials and Methods. Results are expressed as counts per minute (cpm) of [3H] TdR incorporation by responder cells (A) or IL-2–dependent cell line CTL.L (B and C). These results are representative of 3 independent experiments.
