Effect of PAI-1 and VN deficiency on arterial thrombosis.

The carotid arteries of WT mice, mice deficient in PAI-1, and mice deficient in VN were continuously monitored for flow following photochemical injury to the mid common carotid artery. The average time to occlusive thrombosis was longer in mice deficient in PAI-1 and in mice deficient in VN compared with WT mice. The time to clot in PAI-1-deficient mice was also longer than that of VN-deficient mice. ♦, P < .03 compared with VN -/-mice; ♦♦,P < .0001 compared with WT mice; #, P < .01 compared with WT mice.