Nucleotide sequencing analyses of BCL-6 mutations in representative B-cell neoplasms.

The sequence of each case shown in the figure is matched to the sequence of a normal control (N) displaying germline BCL-6 alleles or to the sequence of a tumor sample harboring mutations at a different site. The position of mutations is indicated by the nucleotide number of the corresponding BCL-6 germline sequence (the first nucleotide of the BCL-6 cDNA was arbitrarily chosen as position +1). Cases included in the figure include systemic de novo B-DLCL (1176, 1198, 998), primary central nervous system B-DLCL (1955), and primary splenic B-DLCL (1063, 1569).