Fig. 3.
Fig. 3. Functional characterization of isolated scFv. / Various concentrations of purified patient's IgG (○) and scFv EL-14 (•) were incubated with an equal volume of normal plasma for 2 hours at 37°C. FVIII activity, determined by a one-stage clotting assay, is depicted relative to a control incubation in the absence of IgG and scFv. Similar results were obtained for scFv EL-5, EL-9, EL-16, EL-25, and negative control scFv O4.

Functional characterization of isolated scFv.

Various concentrations of purified patient's IgG (○) and scFv EL-14 (•) were incubated with an equal volume of normal plasma for 2 hours at 37°C. FVIII activity, determined by a one-stage clotting assay, is depicted relative to a control incubation in the absence of IgG and scFv. Similar results were obtained for scFv EL-5, EL-9, EL-16, EL-25, and negative control scFv O4.

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