Rearrangements at the Rh locus giving rise to D-negative and Rh deletion haplotypes.

The structures of the RH locus (located at 1p34-36) that has been defined in various D-negative phenotypes and rare Rh antigen deletion phenotypes are depicted. Each RH gene is represented as 10 boxes, each box representing an exon, where RHCE is shown as gray, RHD as black. Crosshatched boxes depict silent RHDalleles (eg, RHD Q41 X ). The positions of microinsertions or deletions of DNA that cause or are indicative of D-negative phenotypes are shown as triangles. Because exon 8 ofRHCE and RHD are of identical sequence and their origins are not possible to define, they are shaded according to the gene loci position. The significance of these rearrangements, and their impact in particular on molecular genotyping, is discussed within the text. Sources for the information in this figure: DC^W − (AM)184; DC^W − (Glo)185; D−− (LM)186; D−− (Gou)186; D−− (SH)72; D−− and Evans+ D•• (JD)187; Evans+ D•• (AT)69; Evans+ D•• (Dav)186; Dc− (Bol)186; Dc− (LZ)188; Ce70,74,149; r”^G(SF)105,140; (Ce)Ce184; (C)ce^S VS+ (Donor 1077) V−r'^{S 29;98;104}; Amorph Rh_null (BK/DR)176,189; Amorph Rh_null (DAA)177; CML.179