Molecular basis of weak D phenotypes.

This figure depicts missense mutations in the RHD gene associated with weak D phenotypes.92 153 The locations of these mutations on the predicted topology of the RhD protein are depicted as checkered ovals; the D-specific amino acids are shown as open ovals. Most of the missense mutations are located within nonconserved membrane spans (gray) and cytoplasmic regions. Regions of conserved Rh protein family sequence are indicated as black rectangles.