Changes in RHCE.

Amino acids encoded by RHCE are shown by gray boxes, and those encoded by exons from RHD are shown by black boxes. The amino acids associated with E/e and C/c antigens28,93 are shown at the top, and single amino acid changes associated with variant forms of RhCE are shown in the middle. The bottom portion of the figure shows rearrangements of the RHCE and associated antigens. Polymorphism that does not have a 100% correlation with expression of c and C antigens. The information depicted in this figure was obtained from the following sources: Point Mutations35,98,99,104,185,206; Rearrangements D^{HAR 207}; r^G208;$R¯¯$^N90; E Cat II and III185; and Variant e100 101.