Hypothetical model in which NF-E2, GATA-1, and EKLF cooperate to recruit CBP and p300 to the locus control region of the β-globin gene cluster.

This could lead to acetylation of nearby histones and transcription factors. Acetylation of histones leads to changes in chromatin structure, and acetylation of transcription factors might stabilize their interaction with DNA or alter their transcriptional activity. It is conceivable that this high molecular weight complex also connects to the promoters of the globin genes through a looping mechanism.