Fig. 5.
CD38 ligation induces aggregation of murine 32D cells tranfected with human CD38.
Cultures of 32D expressing human CD38 were exposed for 24 hours to a nonreactive isotype-matched control Ig or to 3 preparations of anti-CD38 (THB7): whole Ig molecule, F(ab′)2fragments, and Fab fragments. Cell aggregation was induced by anti-CD38 irrespective of the integrity of the Ig molecule. The loose aggregation seen with control Ig was also seen in cells cultured without antibody (not shown).
