Fig. 8.
CD38 ligation in 32D cells expressing human CD38 induces Ca++ and influx.
Cells were loaded with Indo-1. A shift in Indo-1 fluorescence was induced by the addition of anti-CD38 (THB7) as a whole Ig and F(ab′)2 and Fab fragments. The shift was abrogated by the presence of 5 mM EGTA and was not induced by an isotype-matched nonreactive or by an antibody to CD44, a surface molecule highly expressed in 32D cells.
