Fig. 4.
Cytokine production of chronic lymphocytic leukemia (CLL) B cells and normal B cells in response to DSP30 with or without costimulation with CD40LF cells.
Purified B-CLL cells and B cells from normal control subjects were stimulated with DSP30 at 2 μmol/L with or without 1 × 105 CD40LF. Supernatants were tested for tumor necrosis factor α (A) or interleuken-6 (B) with the use of an enzyme-linked immunosorbent assay system. Results are expressed as mean ± SEM of 11 patients with B-CLL and 7 normal control subjects; n.d. means not detectable.
