Fig. 6.
![Fig. 6. Concentration-dependent inhibition by MPSD of [3H]5-HT output in response to PKC activation. / Platelets were labeled with [3H]5-HT, permeabilized with digitonin, and incubated with 100 nM of PMA in the absence or presence of either MPSD or Ala-MPSD, as indicated in the legend to Figure 5. Inhibition of PMA-induced [3H]5-HT output by different concentrations of MPSD was expressed as a percentage of the [3H]5-HT output in the presence of PMA. Ala-MPSD at the higher concentration tested (10 μM) did not modify the secretory response induced by PMA. Values represent mean ± SEM of 8 different platelet preparations.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/95/3/10.1182_blood.v95.3.894.003k15_894_902/6/bloo00315006x.jpeg?Expires=1735826674&Signature=U5bHGADwJy1~3OwrT8-CMy1klQ~XLSNeIPP1xCPt4PJcLiMDIQJK9NC7e5oJ7BVo734o~fQRz5XbSV73up4-NH-tpcK1I1KcE8m1~IL6HQJ9n~1owq2rIi5GmatwIWhaQlzrOmmDssM3yoBVa7Iz~ormFRC6VE6Xffh5jd7CH37NtdhVqH0aL70ZH9GUVyJl5CgBVj9ZwuX4X1fPSDrQJV1QQokoxpJu0cP6XU5aQRbqIXW8qY56U7ypUI3mb~uNCwUMIlAP2ZzGiY~wNMf8-EhUv3Ub0MFi-pq4hBOf~5SPycJ42DoORLUp~nAm82~iH7G14eM7ZAOAcKZrh89JWw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Concentration-dependent inhibition by MPSD of [3H]5-HT output in response to PKC activation.
Platelets were labeled with [3H]5-HT, permeabilized with digitonin, and incubated with 100 nM of PMA in the absence or presence of either MPSD or Ala-MPSD, as indicated in the legend to Figure 5. Inhibition of PMA-induced [3H]5-HT output by different concentrations of MPSD was expressed as a percentage of the [3H]5-HT output in the presence of PMA. Ala-MPSD at the higher concentration tested (10 μM) did not modify the secretory response induced by PMA. Values represent mean ± SEM of 8 different platelet preparations.
