Fig. 7.
![Fig. 7. Effect of calmodulin and PIP2 on the inhibition by MPSD of [3H]5-HT output in response to PKC activation. / Platelets were labeled with [3H]5-HT, permeabilized with digitonin, and incubated with 100 nM of PMA in the absence or presence of 10 μM of MPSD. When indicated, 10 μM of either calmodulin or PIP2 were present in the incubation medium. [3H]5-HT outputs were expressed as a percentage of total content. Values represent mean ± SEM of at least 8 different platelet preparations.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/95/3/10.1182_blood.v95.3.894.003k15_894_902/6/bloo00315007x.jpeg?Expires=1735503595&Signature=C3Hk5Qr8560fQn3Y720ljlq30D7hlteqdk1zguO5xhybt6EoX5Hkja5XYxeXdCGWNTayH4RyDG6eRUfIwZVhNMC~wEBqvVD4UOzfN3BCur1vwYyzabpvzN-70D4d5AgDqXBvSBMoFp11S7Tlsi1eozxmCqHI8OvvgTCwvMUMoXh457bCZl8u37LB0Rxop0B98UoWfRlxzB1sNp2aNBQRghQzdEiOzk1qRpWaMSCw02vC3X29r23HOOC0GBycIT2nQkieyeQBKNB1uaEcJ~GGzd-NTR1XK-1KrFaTq4cZcHRHWxZMpzkUUenEV9KS3RfU~5W8vVD5d8gPZ~OrDPqmAw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Effect of calmodulin and PIP2 on the inhibition by MPSD of [3H]5-HT output in response to PKC activation.
Platelets were labeled with [3H]5-HT, permeabilized with digitonin, and incubated with 100 nM of PMA in the absence or presence of 10 μM of MPSD. When indicated, 10 μM of either calmodulin or PIP2 were present in the incubation medium. [3H]5-HT outputs were expressed as a percentage of total content. Values represent mean ± SEM of at least 8 different platelet preparations.
