AP1903 produces a transient expansion of CFU-E.

Total BFU-E (A), CFU-E (B), CFU-GM (C), and CFU-Mk (D) values were determined for cord blood transduced with the MFM vector, expanded in the absence and presence of AP1903. Cell expansion occurred in the presence of AP1903, similar to previous experiments (data not shown). BFU-e, CFU-GM, and CFU-Mk values decreased regardless of whether CID was present. CFU-E increased on day 7, then diminished, and was dependent on the presence of AP1903. • = + AP1903; ○ = −AP1903.