Pedigree of the propositus with mutation insT 1689 in the TM gene.

The propositus is indicated by the arrow. Generations are indicated on the left, by roman numerals, individuals in each generation are numbered at the top of the symbols. Clinical data referring to each family member are summarized in Table 1. For each individual the left half of the symbol in black indicates presence of the mutation and the right half of the symbol in black indicates MI in history. nt: not tested.