Lytic bone lesions in the skull, tibia, pelvis, or spine of 10 MM-engrafted mice.

Carcasses of 56 engrafted mice killed at preterminal disease stages, and 12 control mice, were radiographed using mammography. Ten representative radiographs of bones from MM-engrafted mice that had lytic lesions are shown here. The comparable bones from either irradiated or normal control mice did not have detectable lesions (not shown). Each panel is labeled with the source of the engrafting cells and the route of injection. Arrows indicate lytic lesions. The panels are labeled with the patient number from whom the engrafting MM cells were derived (A) Diseased bones (tibias or vertebral body) from mice engrafted IC with aggressive MM cells, or from a secondary recipient mouse (femur). (B) Diseased bones from mice injected IO with aggressive myeloma cells (skull or spine). The middle panel is an enlarged image of the skull lesions. (C) Diseased bones from mice engrafted IC with G-CSF mobilized blood cells (tibia, pelvis, vertebral body, pelvis).