Fig. 7.
Fig. 7. The effect of shear stress on neutrophil adhesion to ICAM-1. / Heterotypic aggregation of neutrophils (1 × 106cells/mL) and 300.19 cells (2 × 106 cells/mL) was measured as described previously in normal HEPES buffer of viscosity 0.7 cp (filled symbols) or in buffer augmented with 6% Ficoll to increase viscosity to 1.7 cp (open symbols). Peak heterotypic aggregation at 1 minute after stimulation with 1 μmol/L fMLP and initiation of shear is plotted versus shear stress for Ilow(circles) and Ihigh (squares). *P < .05 compared with maximum value on the same curve. Data are presented as mean ± SEM from 3 to 6 separate experiments.

The effect of shear stress on neutrophil adhesion to ICAM-1.

Heterotypic aggregation of neutrophils (1 × 106cells/mL) and 300.19 cells (2 × 106 cells/mL) was measured as described previously in normal HEPES buffer of viscosity 0.7 cp (filled symbols) or in buffer augmented with 6% Ficoll to increase viscosity to 1.7 cp (open symbols). Peak heterotypic aggregation at 1 minute after stimulation with 1 μmol/L fMLP and initiation of shear is plotted versus shear stress for Ilow(circles) and Ihigh (squares). *P < .05 compared with maximum value on the same curve. Data are presented as mean ± SEM from 3 to 6 separate experiments.

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