Videomicrographs showing inhibition of PAF-induced SS RBC adhesion in the ex vivo mesocecum vasculature in the presence of MoAb 7E3 F(ab′)2.
(A-C) Ex vivo preparation treated with OC125 F(ab′)2(control antibody) and PAF: (A) clear venular lumen during artificial perfusion with Ringer-albumin; (B) the passage of SS RBCs after a bolus infusion is accompanied by adhesion of these cells in venules; (C) after the passage of the bolus, a large number of SS RBC are seen adhering to the vessel wall during perfusion with Ringer-albumin. (D-F) Ex vivo preparation treated with MoAb 7E3 and PAF: (D) venules during the artificial perfusion; (E) rapid flow of SS RBCs in the vessels after a bolus infusion; (F) after the passage of the bolus, only few SS RBC adhere to the vessel wall. Visit the article on the website (www.bloodjournal.org) to download the video.
