Linear regression plots for the number of adherent SS RBC/100 μm² according to the venular diameter in preparations treated with LM609 (or IgG) and PAF.

In the presence of IgG, PAF caused a pronounced adhesion of SS RBC that was inversely correlated with the vessel diameter (r = −.85,P < .00001). In contrast, LM609 caused a significant inhibition of SS RBC adhesion, particularly in small-diameter venules (the sites of maximal adhesion and frequent blockage), resulting in a lack of correlation between the diameter and the number of adherent cells (r = −.08, P > .68). A comparison of the two linear regression lines confirmed marked differences between intercepts (control Ab/PAF/SS 0.85 ± 0.07, LM609/PAF/SS 0.05 ± 0.02;P < .0001).