![Fig. 2. Effect of Myelopoietin (MPO) administration (200 μg/kg/d) on the bone marrow-derived concentration of GM-CFC, MK-CFC, E-BFU, and GEMM-CFC in 700 cGy total body60Co-γ-irradiated animals. / Clonogenic activity was observed before (baseline [BL]) and on days 7, 14, 21, 48, and 100 after TBI and administration of MPO (n = 4, 200 μg/kg/d, BID) or a control protein (n = 10, HSA or AS) as described in Methods. All animals were assayed at each time point. Clonogenic concentrations (per 105 MNC) are reported as mean values ± SEM. Baseline GEMM-CFC are detectable in low concentration. There is no significant differences between the baseline values of MPO and control-treated animals. Asterisk (*) denotes significantly different from BL (P < .05); Hdenotes significantly greater than control protein, time-matched controls (P < .05); ↓ denotes zero values; ND denotes not done.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/95/3/10.1182_blood.v95.3.837.003k08_837_845/6/bloo00308002x.jpeg?Expires=1743020682&Signature=VQJK6qQqBgZ74Wd2k-1X76~VtO10ZOtnRByfSpCcMdfqaTU1YOGdmUxBaEKXQJnHNGjP6y0Fma1CMbsQPgXnL6c8DjPiKvlJPYznmcKwezd1QTeCwNWrFNePtpNIim3Uz1J~dWBCxUivXuIHtwzpupKFUdxZ9v5El5ZS6pxcv9nm9lfKSXRzd4E~NqBaZbBB3zp2ZHt9SZhTDlORmu35QnzGE-4wylmmHAKNsYnnWno7GZobqlYTWiQtJeukg7xsibYGVeejNoXdUnyE25If7MwkippPdammVWF74Nnu38WHi4f8KO7xcGIsb~Pf3Yyp227Vc920OqRu0zj5BF9VFw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Effect of Myelopoietin (MPO) administration (200 μg/kg/d) on the bone marrow-derived concentration of GM-CFC, MK-CFC, E-BFU, and GEMM-CFC in 700 cGy total body60Co-γ-irradiated animals.
Clonogenic activity was observed before (baseline [BL]) and on days 7, 14, 21, 48, and 100 after TBI and administration of MPO (n = 4, 200 μg/kg/d, BID) or a control protein (n = 10, HSA or AS) as described in Methods. All animals were assayed at each time point. Clonogenic concentrations (per 105 MNC) are reported as mean values ± SEM. Baseline GEMM-CFC are detectable in low concentration. There is no significant differences between the baseline values of MPO and control-treated animals. Asterisk (*) denotes significantly different from BL (P < .05); Hdenotes significantly greater than control protein, time-matched controls (P < .05); ↓ denotes zero values; ND denotes not done.
