Fig. 2.
Fig. 2. Sequence-specific cleavage ofBCR-ABLp190 substrate by M1-p190-GS. / Autoradiograph of cleavage products generated by M1-GS constructs.BCR-ABLp190 substrate was incubated either alone (lane 1), with M1-p190-GS (lane 2), with M1-p210-GS (lane 3), or with M1-TC-GS (lane 4). Schematic representation of specific complexes and products formed by M1-p190-GS and substrates (lane 2) are indicated on the left. However, an inappropriate cleavage was generated under the conditions used in lanes 3 and 4. The nature of these products and of the apparent miscleavages has not been determined.

Sequence-specific cleavage ofBCR-ABLp190 substrate by M1-p190-GS.

Autoradiograph of cleavage products generated by M1-GS constructs.BCR-ABLp190 substrate was incubated either alone (lane 1), with M1-p190-GS (lane 2), with M1-p210-GS (lane 3), or with M1-TC-GS (lane 4). Schematic representation of specific complexes and products formed by M1-p190-GS and substrates (lane 2) are indicated on the left. However, an inappropriate cleavage was generated under the conditions used in lanes 3 and 4. The nature of these products and of the apparent miscleavages has not been determined.

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