Monitoring of EBV-DNA load and CsA levels in patient 6.

A 1-year-old boy with WAS received an unmanipulated bone marrow graft from an unrelated donor. The early posttransplant course was uncomplicated, with no GVHD. However, a mixed chimerism developed. Half of the B cells, granulocytes, and monocytes were of recipient origin, whereas T cells were exclusively of donor extraction. A moderate reticulocytopenia and mild hemolysis were treated with erythropoietin and steroids. Tapering of CsA was initiated but not completed during follow-up. Four EBV-CTL infusions were started on day +97. The EBV-DNA load determined before BMT is shown by an isolated filled circle.