Course of ATIII activity levels in septic baboons treated with rhATIII.

Recombinant human ATIII was infused 1 hour before E coliinfusion, at t = 0, and 3 hours after infusion in concentrations of 66.7, 33.3, and 66.7 mg/kg, respectively (indicated by arrows). ATIII activity levels were measured as previously described. Baboon No. 1 (○), No. 2 (•), No. 3 (▵), No. 4 (▴), and No. 5 (□).