Fibrinolytic response in control and treatment groups.

Mean ± SEM plasma levels of tPA (upper panel), PAI-1 (middle panel), and PAP complexes (lower panel) in control (○) and rhATIII-treated (•) baboons. PAP complexes are expressed as a percentage of NBP-MA-UK. tPA and PAP complex levels were significantly lower in the treatment group compared with controls, whereas PAI-1 levels were significantly higher in the treatment group compared with controls at 2 and 3 hours after the E coli infusion. *P < .05; **P < .01.