Morphological analysis of B-CLL cells exposed to various stimuli for 5 days in vitro.

B-CLL cells (patient B) were exposed to Gaδ-ab + rIL2 (A), rIL2 alone (B), or Gaμ-ab + rIL2 (C). Plasmablasts and plasma cells were observed after culture with Gaδ-ab + rIL2. In contrast, the cells treated with Gaμ-ab were primarily apoptotic or necrotic. Necrosis occurred after apoptosis probably because of the prolonged time in culture (see also Figure 2C). In the preparations exposed to rIL2 only, there were a few surviving small lymphocytes.