Pathologic findings in glomeruli of MRL/lpr mouse kidneys.

A nontreated MRL/lpr mouse (20 weeks old) shows the proliferation of mesangial cells in the glomerulus (left, top) and marked IgG deposits (left, bottom). An MRL/lpr mouse (64 weeks old) treated with (5.5 Gy × 2 + PV + IV) shows normal appearance (right, top) without IgG deposits (right, bottom) 48 weeks after treatment.