Deduced amino acid sequences of the immunoglobulin gene regions (VH-DH-JH) used in the cases of familial CLL.

In each case, the top sequence represents the closest germ line VH genes. The DH and JH segments of the closest germ line are shown. The individual FR and CDR are indicated according to the V BASE sequence directory (I.M. Tomlinson, MRC Center for Protein Engineering, Cambridge, UK). Replacement mutations are shown by uppercase letters and silent mutations by lowercase letters. Identities are represented by dashes.