Fig. 5.
Time course of peptide-induced footpad swelling in infected E/P-sel −/−, E-sel −/−, and wild-type (wt) mice.
Mice were infected iv with 103 LD50 of LCMV and challenged in the right hind footpad with LCMV GP 33-41 (50 μg/mL, 30 μL) on day 8 pi; this peptide represents an immunodominant class I–restricted peptide in H-2b mice. Groups consisted of 4 to 6 mice; medians and ranges are presented. * denotesP < .05 relative to wild-type mice.